NCBI Accession #
NP_172167.2
NCBI GenBank Nucleotide #
NM_100559.4
NCBI Official Full Name
carotenoid isomerase
NCBI Official Symbol
CRTISO
NCBI Official Synonym Symbols
CAROTENOID AND CHLOROPLAST REGULATION 2; carotenoid isomerase; CAROTENOID ISOMERASE; CCR2; F4H5.10; F4H5_10
NCBI Protein Information
carotenoid isomerase
NCBI Summary
Encodes carotenoid isomerase. Catalyzes the isomerization of poly-cis-carotenoids to all-trans-carotenoids. Together with PDS and ZDS, CRTiso is required to complete the synthesis of lycopene from phytoene.
UniProt Synonym Gene Names
CCR2; CrtISO
UniProt Protein Name
Prolycopene isomerase, chloroplastic
UniProt Synonym Protein Names
Carotenoid and chloroplast regulation protein 2; Carotenoid isomerase
UniProt Primary Accession #
Q9M9Y8
UniProt Related Accession #
Q9M9Y8
UniProt Comments
Carotene cis-trans-isomerase that converts 7,9,9'-tri-cis-neurosporene to 9'-cis-neurosporene and 7,9,9',7'-tetra-cis-lycopene (also known as prolycopene) into all-trans-lycopene. Isomerization requires redox-active components, suggesting that isomerization is achieved by a reversible redox reaction acting at specific double bonds. Isomerizes adjacent cis-double bonds at C7 and C9 pairwise into the trans-configuration, but is incapable of isomerizing single cis-double bonds at C9 and C9'. Carotenoid biosynthesis is partly required to form the prolamellar bodies of etioplasts.