NCBI Accession #
NP_194663.1
NCBI GenBank Nucleotide #
NM_119079.4
NCBI Official Full Name
profilin 4
NCBI Official Symbol
PRF4
NCBI Official Synonym Symbols
F17A13.160; F17A13_160; profilin 4
NCBI Protein Information
profilin 4
NCBI Summary
Profilin is a low-molecular weight, actin monomer-binding protein that regulates the organization of actin cytoskeleton in eukaryotes, including higher plants. PRF4 and PRF5 are late pollen-specific and are not detectable in other cell types of the plant body including microspores and root hairs. Immunocytochemical studies at the subcellular level reveal that both the constitutive and pollen-specific profilins are abundant in the cytoplasm. In vegetative cell types, such as root apical cells, profilins showed localization to nuclei in addition to the cytoplasmic staining.
UniProt Synonym Gene Names
PFN3
UniProt Protein Name
Profilin-3
UniProt Primary Accession #
Q38904
UniProt Related Accession #
Q38904
UniProt Comments
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG .