NCBI Accession #
NP_001105451.1
NCBI GenBank Nucleotide #
NM_001111981.2
NCBI Official Full Name
profilin-2
NCBI Official Symbol
prf2
NCBI Official Synonym Symbols
PRO2; Profilin-2; GRMZM2G109842
NCBI Protein Information
profilin-2
UniProt Synonym Gene Names
PRF2
UniProt Protein Name
Profilin-2
UniProt Synonym Protein Names
Pollen allergen Zea m 12; ZmPRO2; Allergen: Zea m 12
UniProt Primary Accession #
P35082
UniProt Related Accession #
P35082
UniProt Comments
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.MiscellaneousThe variability of the residues taking part of IgE-binding epitopes might be responsible of the difference in cross-reactivity among olive pollen cultivars, and between distantly related pollen species, leading to a variable range of allergy reactions among atopic patients.