NCBI Accession #
NP_181381.2
NCBI GenBank Nucleotide #
NM_129404.4
NCBI Official Full Name
WRKY DNA-binding protein 33
NCBI Official Symbol
WRKY33
NCBI Official Synonym Symbols
ATWRKY33; T19C21.4; T19C21_4; WRKY DNA-binding protein 33; WRKY DNA-BINDING PROTEIN 33
NCBI Protein Information
WRKY DNA-binding protein 33
NCBI Summary
Member of the plant WRKY transcription factor family. Regulates the antagonistic relationship between defense pathways mediating responses to P. syringae and necrotrophic fungal pathogens. Located in nucleus. Involved in response to various abiotic stresses - especially salt stress.
UniProt Protein Name
Probable WRKY transcription factor 33
UniProt Synonym Protein Names
WRKY DNA-binding protein 33
UniProt Primary Accession #
Q8S8P5
UniProt Secondary Accession #
Q0WWP2
UniProt Related Accession #
Q8S8P5
UniProt Comments
Transcription factor. Interacts specifically with the W box (5'-TTGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Involved in defense responses. Required for resistance to the necrotrophic fungal pathogen B.cinerea (PubMed:17059405, PubMed:21990940). Regulates the antagonistic relationship between defense pathways mediating responses to the bacterial pathogen P. syringae and the necrotrophic pathogen B.cinerea (PubMed:17059405). Required for the phytoalexin camalexin synthesis following infection with B.cinerea. Acts as positive regulator of the camalexin biosynthetic genes PAD3 (CYP71B15) and CYP71A13 by binding to their promoters (PubMed:21498677, PubMed:22392279). Acts downstream of MPK3 and MPK6 in reprogramming the expression of camalexin biosynthetic genes, which drives the metabolic flow to camalexin production (PubMed:21498677). Functions with WRKY25 as positive regulator of salt stress response and abscisic acid (ABA) signaling (PubMed:18839316). Functions with WRKY25 and WRKY26 as positive regulator of plant thermotolerance by partially participating in ethylene-response signal transduction pathway (PubMed:21336597). The DNA-binding activity of WRKY33 is increased by SIB1 and SIB2 (PubMed:21990940).