NCBI Accession #
NP_181047.1
NCBI GenBank Nucleotide #
NM_129054.4
NCBI Official Full Name
N-acetylglucosamine-1-phosphate uridylyltransferase 2
NCBI Official Symbol
GlcNAc1pUT2
NCBI Official Synonym Symbols
F19I3.25; F19I3_25; GLCNA.UT2; N-acetylglucosamine-1-phosphate uridylyltransferase 2
NCBI Protein Information
N-acetylglucosamine-1-phosphate uridylyltransferase 2
NCBI Summary
Encodes a protein that functions as an N-acetylglucosamine-1-phosphate uridylyltransferase that catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc). This is an essential precursor for glycolipid and glycoprotein synthesis and is also used for regulatory protein modification in signaling pathways. The enzyme can also catalyze the reverse reaction using both UDP-GlcNAc and the less common UDP-N-acetylgalactosamine as substrates. This enzyme can also act on glucose-1-phosphate to produce UDP-glucose.
UniProt Gene Name
GLCNAC1PUT2
UniProt Synonym Gene Names
ATUAP1
UniProt Protein Name
UDP-N-acetylglucosamine diphosphorylase 2
UniProt Synonym Protein Names
N-acetylglucosamine-1-phosphate uridylyltransferase 2; UDP-N-acetylgalactosamine diphosphorylase 2 (EC:2.7.7.83); UTP--glucose-1-phosphate uridylyltransferase 2 (EC:2.7.7.9)
UniProt Primary Accession #
O64765
UniProt Secondary Accession #
Q5PNR7; Q8L9P4
UniProt Related Accession #
O64765
UniProt Comments
Uridylyltransferase involved in the biosynthesis of UDP-glucosamine, an essential precursor for glycoprotein and glycolipid synthesis. Can use UDP-glucosamine, the 4-epimer UDP-galactosamine and UDP-glucose as substrates (PubMed:20557289). Acts redundantly with GLCNAC1PUT1. Required for gametogenesis and embryo development (PubMed:25231969).