Probable serine/threonine-protein kinase GCN2 (GCN2), Recombinant Protein
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Probable serine/threonine-protein kinase GCN2 (GCN2), Recombinant Protein

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Cat: RP02265
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Probable serine/threonine-protein kinase GCN2 (GCN2) , partial
Product Gene Name
GCN2 recombinant protein
Product Synonym Gene Name
GCN2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
140,322 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.

NCBI/Uniprot Data

NCBI Accession #
NP_001326041.1
NCBI GI #
1063717712
NCBI GenBank Nucleotide #
NM_001339969.1
NCBI GeneID
825110
NCBI Official Full Name
protein kinase family protein
NCBI Official Symbol
GCN2
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA GENERAL CONTROL NON-REPRESSIBLE 2; ATGCN2; GENERAL CONTROL NON-REPRESSIBLE 2
NCBI Protein Information
protein kinase family protein
NCBI Summary
Encodes an eIF2alpha kinase that can bind uncharged tRNA via its C-terminus and can phosphorylate both eIF2alpha homologues in Arabidopsis.
UniProt Gene Name
GCN2
UniProt Protein Name
eIF-2-alpha kinase GCN2
UniProt Synonym Protein Names
serine/threonine-protein kinase GCN2
UniProt Primary Accession #
Q9LX30
UniProt Secondary Accession #
Q8H2D3
UniProt Related Accession #
Q9LX30
UniProt Comments
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 eIF-2-alpha in response to low amino acid availability. Plays a role as an activator of the general amino acid control pathway required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha either to a competitive inhibitor of translation initiation, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, and hence allowing reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs.

For research use only, not for clinical use.