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Probable RNA polymerase II transcription factor B subunit 1-3 (TFB1-3), Recombinant Protein
Cat: RP07540
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Probable RNA polymerase II transcription factor B subunit 1-3 (TFB1-3) , partial
Product Gene Name
TFB1-3 recombinant protein
Product Synonym Gene Name
TFB1-3
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
27,680 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Probable RNA polymerase II transcription factor
NCBI/Uniprot Data
NCBI Accession #
NP_191701.4
NCBI GI #
240255685
NCBI GenBank Nucleotide #
NM_116007.5
NCBI GeneID
825315
NCBI Official Full Name
BSD domain (BTF2-like transcription factors, Synapse-associated proteins and DOS2-like proteins)
NCBI Official Symbol
AT3G61420
NCBI Protein Information
BSD domain (BTF2-like transcription factors, Synapse-associated proteins and DOS2-like proteins)
UniProt Gene Name
TFB1-3
UniProt Synonym Gene Names
GTF2H1-2Curated; TFIIH subunit TFB1-3
UniProt Protein Name
General transcription and DNA repair factor IIH subunit TFB1-3
UniProt Synonym Protein Names
RNA polymerase II transcription factor B subunit 1-3
UniProt Primary Accession #
Q9M322
UniProt Secondary Accession #
Q5BIV2; Q67Y79
UniProt Related Accession #
Q9M322
UniProt Comments
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
For research use only, not for clinical use.