NCBI Accession #
NP_179863.1
NCBI GenBank Nucleotide #
NM_127843.5
NCBI Official Full Name
peroxisomal NAD-malate dehydrogenase 1
NCBI Official Symbol
PMDH1
NCBI Official Synonym Symbols
peroxisomal NAD-malate dehydrogenase 1; T30L20.4; T30L20_4
NCBI Protein Information
peroxisomal NAD-malate dehydrogenase 1
NCBI Summary
encodes an peroxisomal NAD-malate dehydrogenase that is involved in fatty acid beta-oxidation through providing NAD to the process of converting fatty acyl CoA to acetyl CoA.
UniProt Synonym Gene Names
Peroxisomal MDH1Curated
UniProt Protein Name
Malate dehydrogenase 1, peroxisomal
UniProt Synonym Protein Names
Peroxisomal NAD-dependent malate dehydrogenase 1
UniProt Primary Accession #
O82399
UniProt Related Accession #
O82399
UniProt Comments
Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Peroxisomal NAD-dependent malate dehydrogenase involved in fatty acid beta-oxidation. Reoxidizes NADH from the beta-oxidation and provides NAD for the conversion of fatty acyl-CoA to acetyl-CoA. Does not participate directly in the glyoxylate cycle (PubMed:17376163, PubMed:19812894). Required for maintenance of photosynthetic rates under photorespiratory conditions, and carbon flow during photorespiration. Supplies NADH reductant to the peroxisomal hydroxypyruvate reductase (HPR), which reduces hydroxypyruvate into glycerate in the photorespiratory cycle (PubMed:18685043).