Products
Online Inquiry
Probable histone-arginine methyltransferase 1.3 (PRMT13), Recombinant Protein
Cat: RP06910
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Probable histone-arginine methyltransferase 1.3 (PRMT13) , partial
Product Gene Name
PRMT13 recombinant protein
Product Synonym Gene Name
PRMT13
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
59,787 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Probable histone-arginine methyltransferase
NCBI/Uniprot Data
NCBI Accession #
NP_187349.2
NCBI GI #
30680066
NCBI GenBank Nucleotide #
NM_111573.5
NCBI GeneID
819878
NCBI Official Full Name
protein arginine methyltransferase 4B
NCBI Official Symbol
PRMT4B
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 4B; ATPRMT4B; protein arginine methyltransferase 4B
NCBI Protein Information
protein arginine methyltransferase 4B
NCBI Summary
Encodes an type I protein arginine methyltransferase. PRMT4b can catalyze the asymmetric dimethylation of arginines 2,17, and 26 on histone 3 and can also methylate myelin basic protein in vitro. Double mutants lacking PRMT4a and 4b have reduced levels of histone 3 methylated at R17. These double mutants flower late due to defects in the autonomous pathway and they have elevated levels of FLC transcripts.
UniProt Gene Name
PRMT13
UniProt Synonym Gene Names
CARM1A; PRMT4B; AtPRMT13; AtPRMT4B
UniProt Protein Name
Probable histone-arginine methyltransferase 1.3
UniProt Synonym Protein Names
Coactivator-associated methyltransferase 1A; Protein arginine N-methyltransferase 4B; AtPRMT4B
UniProt Primary Accession #
Q84W92
UniProt Secondary Accession #
Q0WRU3; Q66GI8; Q9M906
UniProt Related Accession #
Q84W92
UniProt Comments
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability . Recruited to promoters upon gene activation, methylates histone H3 and activates transcription via chromatin remodeling (PubMed:27676073). Positive regulator in the oxidative stress tolerance that promotes the expression of enzymes preventing oxidative stress such as APX1 and GPX1 by histone methylation (H3R17me2a). Confers tolerance to cadmium CdCl2 and salt NaCl stresses (PubMed:27676073).
For research use only, not for clinical use.