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Probable alpha-mannosidase I MNS4 (MNS4), Recombinant Protein
Cat: RP02378
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Probable alpha-mannosidase I MNS4 (MNS4) , partial
Product Gene Name
MNS4 recombinant protein
Product Synonym Gene Name
MNS4
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
70,096 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Alpha-mannosidase
NCBI/Uniprot Data
NCBI Accession #
NP_199184.1
NCBI GI #
15239952
NCBI GenBank Nucleotide #
NM_123737.3
NCBI GeneID
834391
NCBI Official Full Name
Glycosyl hydrolase family 47 protein
NCBI Official Symbol
AT5G43710
NCBI Official Synonym Symbols
mannosidase 4; MNS4; MQD19.4; MQD19_4
NCBI Protein Information
Glycosyl hydrolase family 47 protein
UniProt Gene Name
MNS4
UniProt Protein Name
Alpha-mannosidase I MNS4
UniProt Primary Accession #
Q9FG93
UniProt Related Accession #
Q9FG93
UniProt Comments
Can convert Man9GlcNAc2 and Man8GlcNAc2 into N-glycans with a terminal alpha-1,6-linked Man residue in the C-branch. Functions in the formation of unique N-glycan structures that are specifically recognized by components of the endoplasmic reticulum-associated degradation (ERAD) machinery, which leads to the degradation of misfolded glycoproteins. Most likely generates N-glycan signal on misfolded glycoproteins that is subsequently recognized by OS9. Required for ERAD of the heavily glycosylated and misfolded BRI1 variants BRI1-5 and BRI1-9. Does not seem to play role in N-glycan processing of correctly folded proteins destined for secretion.
For research use only, not for clinical use.