NCBI Accession #
NP_195177.1
NCBI GenBank Nucleotide #
NM_119616.2
NCBI Official Full Name
3-ketoacyl-CoA synthase 17
NCBI Official Symbol
KCS17
NCBI Official Synonym Symbols
3-ketoacyl-CoA synthase 17; KCS17; T4L20.90; T4L20_90
NCBI Protein Information
3-ketoacyl-CoA synthase 17
NCBI Summary
Encodes KCS17, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
UniProt Synonym Gene Names
KCS-2
UniProt Protein Name
Probable 3-ketoacyl-CoA synthase 2
UniProt Synonym Protein Names
Very long-chain fatty acid condensing enzyme 2
UniProt Entry Name
KCS2_ARATH
UniProt Primary Accession #
O65677
UniProt Related Accession #
O65677
UniProt Comments
Function: Active on saturated acyl-CoAs up to C22. Mediates the synthesis of VLCFAs from 20 to 26 carbons in length (e.g. C20:1, C20, C24, C26).Catalytic activity: Stearoyl-CoA + malonyl-CoA + 2 NAD(P)H = icosanoyl-CoA + CO2 + CoA + 2 NAD(P)+ + H2O.A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.Enzyme regulation: Inhibited by K3 herbicides such as alachlor, allidochlor, anilofos, cafenstrole, fentrazamide and flufenacet.Pathway: Lipid metabolism; fatty acid biosynthesis.Subcellular location: Membrane; Multi-pass membrane protein Potential. Induction: Repressed by herbicides such as flufenacet and benfuresate.Sequence similarities: Belongs to the chalcone/stilbene synthases family.Contains 1 FAE (fatty acid elongase) domain.