NCBI Accession #
NP_196445.1
NCBI GenBank Nucleotide #
NM_120911.4
NCBI Official Full Name
hydroxymethylbilane synthase
NCBI Official Symbol
HEMC
NCBI Official Synonym Symbols
F8L15.10; F8L15_10; hydroxymethylbilane synthase; PORPHOBILINOGEN DEAMINASE; RUG1; RUGOSA 1
NCBI Protein Information
hydroxymethylbilane synthase
NCBI Summary
Encodes a protein with porphobilinogen deaminase activity. This protein is targeted to the chloroplast. Mutants spontaneously develop chlorotic leaf lesions in the absence of pathogen attack, resembling the phenotype of lesion-mimic mutants.
UniProt Synonym Gene Names
RUG1; PBG; HMBS
UniProt Protein Name
Porphobilinogen deaminase, chloroplastic
UniProt Synonym Protein Names
Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase; Protein RUGOSA1
UniProt Primary Accession #
Q43316
UniProt Secondary Accession #
Q8LBT0
UniProt Related Accession #
Q43316
UniProt Comments
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.