NCBI Accession #
NP_188194.1
NCBI GenBank Nucleotide #
NM_112443.3
NCBI Official Full Name
phospholipase D alpha 1
NCBI Official Symbol
PLDALPHA1
NCBI Official Synonym Symbols
PHOSPHOLIPASE D; phospholipase D alpha 1; PLD
NCBI Protein Information
phospholipase D alpha 1
NCBI Summary
Encodes phospholipase D alpha 1 (PLD alpha 1). Positive regulator of abscisic acid (ABA) mediated stomatal movements. PLD alpha 1 plays an important role in seed deterioration and aging in Arabidopsis.
UniProt Gene Name
PLDALPHA1
UniProt Synonym Gene Names
PLD alpha 1
UniProt Protein Name
Phospholipase D alpha 1
UniProt Synonym Protein Names
Choline phosphatase 1; PLDalpha
UniProt Primary Accession #
Q38882
UniProt Secondary Accession #
Q0WV84; Q944M4; Q9LW06
UniProt Related Accession #
Q38882
UniProt Comments
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Plays an important role in various cellular processes, including phytohormone action and response to stress, characterized by acidification of the cell (PubMed:9437863). Involved in wound induction of jasmonic acid (PubMed:11090221). May be involved in membrane lipid remodeling (PubMed:11239826). Probably involved in freezing tolerance by modulating the cold-responsive genes and accumulation of osmolytes (PubMed:16949955). Can use phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) as substrates, both in presence or in absence of PIP2 (PubMed:9578608). Its main substrate is phosphatidylcholine (PubMed:11239826). Stimulates the intrinsic GTPase activity of GPA1 upon binding (PubMed:14594812). Mediates the abscisic acid effects on stomata through interaction with GPA1 and the production of phosphatidic acid that bind to ABI1 (PubMed:17261695, PubMed:17565616). Involved in seed aging and deterioration (PubMed:17565616). Involved in microtubule stabilization and salt tolerance (PubMed:23150630). Involved in abscisic acid-induced stomatal closure (PubMed:22392280).