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Peroxisome biogenesis protein 5 (PEX5), Recombinant Protein
Cat: RP03014
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Peroxisome biogenesis protein 5 (PEX5) , partial
Product Gene Name
PEX5 recombinant protein
Product Synonym Gene Name
PEX5
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
80,912 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Peroxisome biogenesis protein
NCBI/Uniprot Data
NCBI Accession #
NP_200440.1
NCBI GI #
15241175
NCBI GenBank Nucleotide #
NM_125012.5
NCBI GeneID
835728
NCBI Official Full Name
peroxin 5
NCBI Official Symbol
PEX5
NCBI Official Synonym Symbols
ARABIDOPSIS PEROXIN 5; ATPEX5; EMB2790; EMBRYO DEFECTIVE 2790; MXK23.3; MXK23_3; peroxin 5
NCBI Protein Information
peroxin 5
NCBI Summary
Encodes the peroxisomal targeting signal type 1 receptor that facilitates peroxisomal protein translocation. It recognizes proteins with the PTS1 consensus sequence (tripeptide SKL or a conserved variant) at the extreme C terminus. The protein has several domains, including C-terminal tetratricopeptide repeat motifs which act in binding the C-terminal ''SKL'' targeting signal. The mechanism of transport has been worked out in other organisms: The receptor recognizes and binds cytosolic PTS1-containing proteins. The PEX5-PTS1 complex binds a PEX14/PEX13 receptor complex at the peroxisome membrane and is translocated into the peroxisome matrix in a process dependent on PEX2,PEX10, and PEX12. In the peroxisome matrix, PEX5 releases its cargo and is recycled to the cytosol in a process dependent on PEX1, PEX4, PEX6 and PEX22. It is also involved, in conjunction with PEX7, in PTS1- and PTS2-dependent peroxisomal protein import. RNAi experiments suggest that PEX5 is necessary for the maintenance of both glyoxysomal and leaf peroxisomal functions.
UniProt Gene Name
PEX5
UniProt Synonym Gene Names
AtPEX5
UniProt Protein Name
Peroxisome biogenesis protein 5
UniProt Synonym Protein Names
Peroxin-5; AtPEX5; Peroxisomal targeting signal type 1 receptor; Pex5p
UniProt Primary Accession #
Q9FMA3
UniProt Secondary Accession #
O82467
UniProt Related Accession #
Q9FMA3
UniProt Comments
Import receptor for peroxisomal-targeting signal one (PTS1). A receptor-cargo complex composed of PEX5, PEX7, a PTS1-containing protein and a PTS2-containing protein is targeted to peroxisomes during import. Necessary for the developmental elimination of obsolete peroxisome matrix proteins.
For research use only, not for clinical use.