NCBI Accession #
NP_567717.1
NCBI GenBank Nucleotide #
NM_118666.3
NCBI Official Full Name
FK506 BINDING PROTEIN 53
NCBI Official Symbol
FKBP53
NCBI Official Synonym Symbols
ATFKBP53; FK506 BINDING PROTEIN 53; T30C3.20; T30C3_20
NCBI Protein Information
FK506 BINDING PROTEIN 53
NCBI Summary
Encodes a member of the FKBP-type immunophilin family that functions as a histone chaparone. Binds to 18S rDNA and represses its expression.
UniProt Synonym Gene Names
PPIase FKBP53; AtFKBP53
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP53
UniProt Synonym Protein Names
FK506-binding protein 53; AtFKBP53; Immunophilin FKBP53; Rotamase
UniProt Primary Accession #
Q93ZG9
UniProt Secondary Accession #
Q9STK2
UniProt Related Accession #
Q93ZG9
UniProt Comments
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides . Histone chaperone possibly involved in H3/H4 deposition to the nucleosome. Associates with 18S rDNA chromatin and negatively regulates the level of its expression.