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Peptidyl-prolyl cis-trans isomerase FKBP42 (FKBP42), Recombinant Protein
Cat: RP07732
Size: 0.02 mg/ 0.1 mg/ 5x0.1 mg
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Peptidyl-prolyl cis-trans isomerase FKBP42 (FKBP42)
Product Gene Name
FKBP42 recombinant protein
Product Synonym Gene Name
TWD1; UCU2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MDESLEHQTQ THDQESEIVT EGSAVVHSEP SQEGNVPPKV DSEAEVLDEK VSKQIIKEGH GSKPSKYSTC FLHYRAWTKN SQHKFEDTWH EQQPIELVLG KEKKELAGLA IGVASMKSGE RALVHVGWEL AYGKEGNFSF PNVPPMADLL YEVEVIGFDE TKEGKARSDM TVEERIGAAD RRKMDGNSLF KEEKLEEAMQ QYEMAIAYMG DDFMFQLYGK YQDMALAVKN PCHLNIAACL IKLKRYDEAI GHCNIVLTEE EKNPKALFRR GKAKAELGQM DSARDDFRKA QKYAPDDKAI RRELRALAEQ EKALYQKQKE MYKGIFKGKD EGGAKSKSLF WLIVLWQWFV SLFSRIFRRH RVKAD
Sequence Positions
1-365aa; full length protein
Format
Liquid containing glycerol
Host
Cell Free Expression
Molecular Weight
41,806 Da
Storage
Store at -20℃, for extended storage, conserve at -20℃ or -80℃.Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Protein Family
Peptidyl-prolyl cis-trans isomerase
NCBI/Uniprot Data
NCBI Accession #
NP_188801.2
NCBI GI #
30686321
NCBI GenBank Nucleotide #
NM_113059.2
NCBI GeneID
821718
NCBI Official Full Name
putative peptidyl-prolyl cis-trans isomerase FKBP42
NCBI Official Symbol
TWD1
NCBI Official Synonym Symbols
ATFKBP42; FK506-BINDING PROTEIN 42; FKBP42; TWD1; TWISTED DWARF 1; UCU2; ULTRACURVATA 2
NCBI Protein Information
putative peptidyl-prolyl cis-trans isomerase FKBP42
NCBI Summary
encodes a 42 kDa FK506-binding protein (AtFKBP42) that possesses similarity to multidomain peptidyl-prolyl cis/trans isomerases (PPIases, EC 5.2.1.8), which are known to be components of mammalian steroid hormone receptor complexes. The protein appears to be localized to the plasma membrane by electron microscopy and binds to HSP90.1 and calmodulin in vitro. It also aggregates citrate synthase in vitro but does NOT show PPIase activity in vivo. Mutants are reduced in size and exhibit disoriented growth in all organs.
UniProt Gene Name
FKBP42
UniProt Synonym Gene Names
TWD1; UCU2; PPIase FKBP42; AtFKBP42
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP42
UniProt Synonym Protein Names
42 kDa peptidyl-prolyl isomerase; FK506-binding protein 42; AtFKBP42; Immunophilin FKBP42; Protein TWISTED DWARF 1; Protein ULTRACURVATA 2; Rotamase
UniProt Entry Name
FKB42_ARATH
UniProt Primary Accession #
Q9LDC0
UniProt Secondary Accession #
Q8RWM0
UniProt Related Accession #
Q9LDC0
UniProt Comments
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides . Modulates the uptake of MRP substrates into the vacuole; reduces metolachlor-GS (MOC-GS) and enhances 17-beta-estradiol 17-(beta-D-glucuronide) (E217betaG) uptake. Regulates cell elongation and orientation. Functions as a positive regulator of PGP1-mediated auxin transport. Confers drug modulation of PGP1 efflux activity as interaction with NPA or flavonol quercetin prevents its physical and functional interaction with PGP1. Required for the proper localization of auxin-related ABCB transporters. Plays a role in brassinosteroid (BR) signaling pathway.
For research use only, not for clinical use.