Nudix hydrolase 1 (NUDT1), Recombinant Protein
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Nudix hydrolase 1 (NUDT1), Recombinant Protein

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Cat: RP04025
Size: 0.02 mg (E-Coli)/ 0.1 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 1 mg (E-Coli)/ 0.1 mg (Baculovirus)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Nudix hydrolase 1 (NUDT1)
Product Gene Name
NUDT1 recombinant protein
Product Synonym Gene Name
NUDT1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MSTGEAIPRV AVVVFILNGN SILLGRRRSS IGNSTFALPG GHLEFGESFE ECAAREVMEE TGLKIEKMKL LTVTNNVFKE APTPSHYVSV SIRAVLVDPS QEPKNMEPEK CEGWDWYDWE NLPKPLFWPL EKLFGSGFNP FTHGGGD
Sequence Positions
1-147, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
16,357 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Nudix hydrolase

NCBI/Uniprot Data

NCBI Accession #
NP_177044.1
NCBI GI #
15221521
NCBI GenBank Nucleotide #
NM_105549.4
NCBI GeneID
843207
NCBI Official Full Name
nudix hydrolase 1
NCBI Official Symbol
NUDX1
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA NUDIX HYDROLASE HOMOLOG 1; ATNUDT1; ATNUDX1; F14K14.13; F14K14_13; nudix hydrolase 1; nudix hydrolase 1; NUDIX HYDROLASE 1
NCBI Protein Information
nudix hydrolase 1
NCBI Summary
Encodes a cytosol-localized nudix hydrolase that hydrolyzes 8-oxo-(d)GTP to its monophosphate form. This protective mechanism prevents the misincorporation of these oxidized nucleotides into DNA and RNA. NUDX1 also has a low level of dihydroneopterin triphosphate pyrophosphatase activity in vitro and may participate in the folate synthesis pathway.
UniProt Gene Name
NUDT1
UniProt Synonym Gene Names
NUDX1; DHNTP pyrophosphohydrolase
UniProt Protein Name
Nudix hydrolase 1
UniProt Synonym Protein Names
7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTP diphosphatase (EC:3.6.1.55); 8-oxo-dGTPase; Dihydroneopterin triphosphate diphosphatase (EC:3.6.1.67
UniProt Primary Accession #
Q9CA40
UniProt Related Accession #
Q9CA40
UniProt Comments
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Its substrate specificity is unclear. In vitro, it can use NTP, dNTP, 8-oxo-GTP, 8-oxo-dGTP, dGTP, dATP, dTTP or dihydroneopterin triphosphate (DHNTP) as substrate. Has some NADH pyrophosphatase activity in vitro; however, such activity may not be relevant in vivo due to the high concentration of manganese used during the experiments. Plays an important role in protection against oxidative DNA and RNA damage by removing oxidatively damaged form of guanine.

For research use only, not for clinical use.