NCBI Accession #
NP_568970.2
NCBI GenBank Nucleotide #
NM_125726.4
NCBI Official Full Name
nucleoside diphosphate kinase 2
NCBI Official Symbol
NDPK2
NCBI Official Synonym Symbols
ARABIDOPSIS NUCLEOSIDE DIPHOSPHATE KINASE 2; ATNDPK2; MDC12.28; MDC12_28; NDP KINASE 1A; NDPK IA; NDPK IA IA; NDPK1A; nucleoside diphosphate kinase 2; NUCLEOSIDE DIPHOSPHATE KINASE IA
NCBI Protein Information
nucleoside diphosphate kinase 2
NCBI Summary
Maintains intracellular dNTP levels except ATP. Plays a role in response to oxidative stress and UV. Involved in phytochrome-mediated light signaling. Participates in auxin-regulated processes, partly through the modulation of auxin transport. H-bonding with His-197 inside the nucleotide-binding pocket is critical for NDPK2 functioning.
UniProt Synonym Gene Names
NDK II; NDP kinase II; NDPK II; NDPK Ia
UniProt Protein Name
Nucleoside diphosphate kinase II, chloroplastic
UniProt Primary Accession #
O64903
UniProt Secondary Accession #
O65212; Q9SMX6
UniProt Related Accession #
O64903
UniProt Comments
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. May activate MPK3 and MPK6. May be involved in the regulation of cellular redox state and hydrogen peroxide-mediated MAP kinase signaling.