NCBI Accession #
NP_565416.1
NCBI GenBank Nucleotide #
NM_127302.3
NCBI Official Full Name
Seven transmembrane MLO family protein
NCBI Official Symbol
MLO8
NCBI Official Synonym Symbols
ATMLO8; F5J6.21; MILDEW RESISTANCE LOCUS O 8
NCBI Protein Information
Seven transmembrane MLO family protein
NCBI Summary
A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO8 belongs to the clade III, with AtMLO5, AtMLO7, AtMLO9, and AtMLO10. The gene is expressed during seedling growth, in cotyledons and hypocotyl, and in fruit abscission zone, as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s).
UniProt Synonym Gene Names
AtMlo8
UniProt Protein Name
MLO-like protein 8
UniProt Primary Accession #
O22757
UniProt Secondary Accession #
Q94KB5; Q9SHM0
UniProt Related Accession #
O22757
UniProt Comments
May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca2+-dependent calmodulin binding and seems not to require heterotrimeric G proteins .