NCBI Accession #
NP_180923.1
NCBI GenBank Nucleotide #
NM_128925.1
NCBI Official Full Name
MLO-like protein 5
NCBI Official Symbol
MLO5
NCBI Official Synonym Symbols
ATMLO5; F4P9.44; F4P9_44; MILDEW RESISTANCE LOCUS O 5; MLO5
NCBI Protein Information
MLO-like protein 5
NCBI Summary
A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO5 belongs to the clade III, with AtMLO7, AtMLO8, AtMLO9, and AtMLO10. The gene is expressed during seedling growth, in cotyledon vascular system, and in stigma, anther and pollen grains; it was not expressed in rosette leaves, as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s).
UniProt Synonym Gene Names
AtMlo5
UniProt Protein Name
MLO-like protein 5
UniProt Entry Name
MLO5_ARATH
UniProt Primary Accession #
O22815
UniProt Related Accession #
AAC69142
UniProt Comments
Function: May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca2+-dependent calmodulin binding and seems not to require heterotrimeric G proteins By similarity.Subcellular location: Membrane; Multi-pass membrane protein By similarity. Domain: The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion By similarity.Sequence similarities: Belongs to the MLO family.