NCBI Accession #
NP_172598.1
NCBI GenBank Nucleotide #
NM_101004.3
NCBI Official Full Name
MLO-like protein 2
NCBI Official Symbol
MLO2
NCBI Official Synonym Symbols
ATMLO2; MILDEW RESISTANCE LOCUS O 2; MLO2; PMR2; POWDERY MILDEW RESISTANT 2; T28P6.4; T28P6_4
NCBI Protein Information
MLO-like protein 2
NCBI Summary
A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO2 belongs to the clade IV, with AtMLO3, AtMLO6 and AtMLO12. The gene is expressed during early seedling growth, in roots, in vascular system of cotyledons and young leaves,and in fruit abscission zone; it was not expressed in anthers and pollen, as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s). mlo resistance in A. thaliana does not involve the signaling molecules ethylene, jasmonic acid or salicylic acid, but requires a syntaxin, glycosyl hydrolase and ABC transporter.
UniProt Synonym Gene Names
AtMlo2
UniProt Protein Name
MLO-like protein 2
UniProt Entry Name
MLO2_ARATH
UniProt Primary Accession #
Q9SXB6
UniProt Related Accession #
Q9SXB6
UniProt Comments
May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca2+-dependent calmodulin binding and seems not to require heterotrimeric G proteins .