NCBI Accession #
NP_181939.1
NCBI GenBank Nucleotide #
NM_129974.1
NCBI Official Full Name
MLO-like protein 15
NCBI Official Symbol
MLO15
NCBI Official Synonym Symbols
ATMLO15; F6E13.24; MILDEW RESISTANCE LOCUS O 15; MLO15
NCBI Protein Information
MLO-like protein 15
NCBI Summary
A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO15 belongs to the clade II, with ATMLO13 and ATMLO15. The gene is expressed during early seedling growth, in root tips and flower (papillae, anthers and pollen grains), as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s).
UniProt Synonym Gene Names
AtMlo15
UniProt Protein Name
MLO-like protein 15
UniProt Entry Name
MLO15_ARATH
UniProt Primary Accession #
O80580
UniProt Related Accession #
O80580
UniProt Comments
Function: May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca2+-dependent calmodulin binding and seems not to require heterotrimeric G proteins By similarity.Subcellular location: Membrane; Multi-pass membrane protein By similarity. Domain: The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion By similarity.Sequence similarities: Belongs to the MLO family.