NCBI Accession #
NP_001031578.1
NCBI GenBank Nucleotide #
NM_001036501.2
NCBI Official Full Name
Seven transmembrane MLO family protein
NCBI Official Symbol
MLO1
NCBI Official Synonym Symbols
ATMLO1; MILDEW RESISTANCE LOCUS O 1; T10P11.12; T10P11_12
NCBI Protein Information
Seven transmembrane MLO family protein
NCBI Summary
A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO1 belongs to the clade II, with ATMLO13 and ATMLO15. The gene is expressed during early seedling growth, in root and cotyledon vascular system, in pollen and in papillae, as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s).
UniProt Synonym Gene Names
MLO-H1; AtMlo1; AtMlo-H1
UniProt Protein Name
MLO-like protein 1
UniProt Synonym Protein Names
MLO protein homolog 1; AtMlo-H1
UniProt Primary Accession #
O49621
UniProt Secondary Accession #
O22766
UniProt Related Accession #
O49621
UniProt Comments
May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca2+-dependent calmodulin binding and seems not to require heterotrimeric G proteins .