NCBI Accession #
NP_001319606.1
NCBI GenBank Nucleotide #
NM_001338511.1
NCBI Official Full Name
MAP kinase kinase 5
NCBI Official Symbol
MKK5
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5; ATMAP2K_ALPHA; ATMEK5; ATMKK5; MAP kinase kinase 5; MAP KINASE KINASE 5; MAP2K_A; MEK5
NCBI Protein Information
MAP kinase kinase 5
NCBI Summary
Encodes a mitogen-activated kinase kinase, dual specific protein kinase that is expressed in vegetative tissues and floral buds. Involved in innate immunity. This protein activates MPK3/MPK6 and early-defense genes redundantly with MKK4.In plants with both MKK5 and MKK6 levels reduced by RNAi plants, floral organs do not abscise suggestion a role for both proteins in mediating floral organ abscission.
UniProt Synonym Gene Names
MEK5; AtMAP2Kalpha; AtMEK5; AtMKK5; MAP kinase kinase 5
UniProt Protein Name
Mitogen-activated protein kinase kinase 5
UniProt Primary Accession #
Q8RXG3
UniProt Secondary Accession #
O80398; Q96517
UniProt Related Accession #
Q8RXG3
UniProt Comments
Involved in the second phase of hydrogen peroxide generation during hypersensitive response-like cell death. Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. Activates by phosphorylation the downstream MPK3 and MPK6. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the morphology of plant organs. MKK4 and MKK5 participate in the regulation of floral organ abscission. Target of the Pseudomonas syringae type III effector HopF2, that inhibits the activation of the downstream MPK6 and PAMP-triggered immunity. Plays a critical role in high light stress tolerance by the mediation of the Cu/Zn SODs CSD1 and CSD2 gene expression. Phosphorylates BZR1 in vitro.