NCBI Accession #
NP_199894.1
NCBI GenBank Nucleotide #
NM_124459.4
NCBI Official Full Name
translocase inner membrane subunit 8
NCBI Official Symbol
TIM8
NCBI Official Synonym Symbols
K7B16.3; K7B16_3; translocase inner membrane subunit 8
NCBI Protein Information
translocase inner membrane subunit 8
NCBI Summary
Encodes a small zinc finger-like protein that is a component of the mitochondrial protein import apparatus.
UniProt Protein Name
Mitochondrial import inner membrane translocase subunit TIM8
UniProt Primary Accession #
Q9XGY4
UniProt Related Accession #
Q9XGY4
UniProt Comments
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex mediates the import of some proteins while the predominant TIM9-TIM10 70 kDa complex mediates the import of much more proteins .