Methyl-CpG-binding domain-containing protein 7 (MBD7), Recombinant Protein
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Methyl-CpG-binding domain-containing protein 7 (MBD7), Recombinant Protein

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Cat: RP02637
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Methyl-CpG-binding domain-containing protein 7 (MBD7)
Product Gene Name
MBD7 recombinant protein
Product Synonym Gene Name
MBD7
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MQTRSSSSPS ANHRRETQLQ IADPTSFCGK IMPGWTVVNR PRSSNNGVVD TYFIEPGTGR QFSSLEAIHR HLAGEVNDRR LTRAGSFFQD KTRVYEGSRT KQDHCGVEYA SKGFRLPRGW SVEEVPRKNS HYIDKYYVER KTGKRFRSLV SVERYLRESR NSIEQQLRVL QNRRGHSKDF RLPDGWIVEE KPRRSSSHID RSYIEPGTGN KFRSMAAVER YLISVGNITL DSVSMVHSER LPLLMNRNGI RFQSEVIDPN PPKKVKWVLT GSGGNMFTAN VRGSNVSSLV KHTWSEAFVS LIEDRS
Sequence Positions
1-306, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
24,038 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Methyl-CpG-binding domain-containing protein

NCBI/Uniprot Data

NCBI Accession #
NP_200788.1
NCBI GI #
15238536
NCBI GenBank Nucleotide #
NP_200788.1
NCBI Official Full Name
methyl-CPG-binding domain 7
UniProt Gene Name
MBD7
UniProt Synonym Gene Names
MBD07
UniProt Protein Name
Methyl-CpG-binding domain-containing protein 7
UniProt Synonym Protein Names
Methyl-CpG-binding protein MBD7
UniProt Primary Accession #
Q9FJF4
UniProt Comments
Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. May directly affect chromatin structure by inducing intra- and inter- chromatin compaction via bridging over multiple methylated CpG sites. Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression (PubMed:25684209). Requires high mCG density for binding (PubMed:25684209, PubMed:25593350). Recognizes preferentially mCGs located in transposable elements (PubMed:25684209, PubMed:25593350). Required for active DNA demethylation (PubMed:25593350). Prefers to target genomic loci around chromocenters (PubMed:25593350).

For research use only, not for clinical use.