NCBI Accession #
NP_187461.1
NCBI GenBank Nucleotide #
NM_111683.2
NCBI Official Full Name
MATE efflux family protein
NCBI Official Symbol
FRD3
NCBI Official Synonym Symbols
ATFRD3; FERRIC REDUCTASE DEFECTIVE 3; MAN1; MANGANESE ACCUMULATOR 1
NCBI Protein Information
MATE efflux family protein
NCBI Summary
Encodes a member of the MATE (multidrug and toxin efflux family), expressed in roots but not shoots. Mutants accumulate excess iron, manganese and zinc, and express root Fe(III) chelatase activity even under iron sufficiency conditions. FRD3 is likely to function in root xylem loading of an iron chelator or other factor necessary for efficient iron uptake out of the xylem or apoplastic space and into leaf cells.
UniProt Synonym Gene Names
AtFRD3
UniProt Protein Name
Protein DETOXIFICATION 43
UniProt Synonym Protein Names
Multidrug and toxic compound extrusion protein 43
UniProt Primary Accession #
Q9SFB0
UniProt Related Accession #
Q9SFB0
UniProt Comments
Citrate transporter responsible for loading citrate into xylem tissues, which helps facilitate iron transport to shoots (PubMed:12172022, PubMed:15310833, PubMed:17351051, PubMed:18826429). Mediates the citrate release in the apoplastic spaces during plant development allowing iron nutrition between symplastically disconnected tissues (PubMed:21742986).