NCBI Accession #
NP_564333.1
NCBI GenBank Nucleotide #
NM_102709.4
NCBI Official Full Name
MAC/Perforin domain-containing protein
NCBI Official Symbol
CAD1
NCBI Official Synonym Symbols
constitutively activated cell death 1; F15D2.24; F15D2_24; necrotic spotted lesion 2; NSL2
NCBI Protein Information
MAC/Perforin domain-containing protein
NCBI Summary
Encodes a protein containing a domain with significant homology to the MACPF (membrane attack complex and perforin) domain of complements and perforin proteins that are involved in innate immunity in animals. Transgenic cad1-1 mutant plants show lesions seen in the hypersensitive response, as well as a spontaneous activation of expression of pathogenesis-related genes and leading to a 32-fold increase in salicylic acid (SA). CAD1 is postulated to act as a negative regulator controlling SA-mediated pathway of programmed cell death in plant immunity.
UniProt Synonym Gene Names
Protein CAD1
UniProt Protein Name
MACPF domain-containing protein CAD1
UniProt Synonym Protein Names
Protein CONSTITUTIVELY ACTIVATED CELL DEATH 1; Protein CAD1
UniProt Primary Accession #
Q9C7N2
UniProt Secondary Accession #
Q940R0
UniProt Related Accession #
Q9C7N2
UniProt Comments
Negatively controls the salicylic acid (SA)-mediated pathway of programmed cell death in plant immunity.