NCBI Accession #
NP_001031554.1
NCBI GenBank Nucleotide #
NM_001036477.1
NCBI Official Full Name
AMP-dependent synthetase and ligase family protein
NCBI Official Symbol
LACS1
NCBI Official Synonym Symbols
CER8; ECERIFERUM 8; LONG-CHAIN ACYL-COA SYNTHASE 1; T8I13.8
NCBI Protein Information
AMP-dependent synthetase and ligase family protein
NCBI Summary
Encodes an acyl-CoA synthetase that acts on long-chain and very-long-chain fatty acids, involved in cuticular wax and cutin biosynthesis
UniProt Synonym Gene Names
CER8
UniProt Protein Name
Long chain acyl-CoA synthetase 1
UniProt Synonym Protein Names
Protein ECERIFERUM 8
UniProt Primary Accession #
O22898
UniProt Secondary Accession #
Q56WP3; Q56ZG8
UniProt Related Accession #
O22898
UniProt Comments
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Acts in both the wax and cutin pathways. Preferentially uses palmitate, palmitoleate, linoleate and eicosenoate. Seems to have a specific activity against very long-chain fatty acid (VLCFA) class with acids longer than 24 carbons (C(24)).