NCBI Accession #
NP_001077777.1
NCBI GenBank Nucleotide #
NM_001084308.5
NCBI Official Full Name
Lateral organ boundaries (LOB) domain family protein
NCBI Official Synonym Symbols
ASYMMETRIC LEAVES 2; F5I14.15; F5I14_15
NCBI Protein Information
Lateral organ boundaries (LOB) domain family protein
NCBI Summary
required for formation of a symmetric flat leaf lamina, encodes a member of a family of proteins characterized by cysteine repeats and a leucine zipper; involved in KNOX gene regulation. Acts together with ASL1 in proximal-distal symmetry determination. Forms a complex with AS1 that binds to the BP promoter and leads to silencing of BP.
UniProt Synonym Gene Names
AS2
UniProt Protein Name
LOB domain-containing protein 6
UniProt Synonym Protein Names
Protein ASYMMETRIC LEAVES 2
UniProt Primary Accession #
O04479
UniProt Secondary Accession #
Q53YQ2; B7XG54
UniProt Related Accession #
O04479
UniProt Comments
Negative regulator of cell proliferation in the adaxial side of leaves. Regulates the formation of a symmetric lamina and the establishment of venation. Positively regulates LATERAL ORGAN BOUNDARIES (LOB) within the shoot apex, and the class III HD-ZIP genes REV, PHB, and PHV. Interacts directly with ASYMMETRIC LEAVES 1 (AS1) to repress the knox homeobox genes BP/KNAT1, KNAT2, and KNAT6 and the abaxial determinants ARF3/ETT, KAN2 and YAB5. May act in parallel with the RDR6-SGS3-AGO7 pathway, an endogenous RNA silencing pathway, to regulate the leaf morphogenesis (PubMed:11311158, PubMed:12787254, PubMed:12874130, PubMed:14508003, PubMed:16006579, PubMed:16699177, PubMed:17395603, PubMed:17559509). Required for the binding of AS1 to the KNOX genes (PubMed:23271976).