Lens-Conjugating Agglutinin (LCA) consists of an alpha-chain (molecular weight: 5.7 kDa) and a beta-chain (molecular weight: 17.5 kDa). It is carbohydrate specific for β- d -mannose and β- d -glucose. This lectin is used in affinity chromatography columns for the separation of glycoconjugates. Two isoforms, LCA-A and LCA-B, agglutinate human erythrocytes, although not blood group specific.LCA activity is determined by agglutination with human blood and a 2% suspension of human erythrocytes at a lectin concentration of 8 µg/ml.LCA requires calcium and manganese ions for binding. See other LCA conjugates.
For research use only, not for clinical use.