NCBI Accession #
NP_188557.1
NCBI GenBank Nucleotide #
NM_112813.2
NCBI Official Full Name
LAG1 homologue 2
NCBI Official Symbol
LOH2
NCBI Official Synonym Symbols
LAG1 HOMOLOG 2; LAG1 homologue 2; LONGEVITY ASSURANCE GENE1 HOMOLOG 2
NCBI Protein Information
LAG1 homologue 2
NCBI Summary
LAG1 homolog . Loss of function mutant is sensitive to AAL-toxin. LOH2 is presumed to function in sphingolipid metabolism. It encodes a ceramide synthase essential for production of LCFA-ceramides (mainly C26).
UniProt Synonym Gene Names
LAG1 homolog 2
UniProt Protein Name
LAG1 longevity assurance homolog 2
UniProt Primary Accession #
Q9LJK3
UniProt Secondary Accession #
Q9M6A2
UniProt Related Accession #
Q9LJK3
UniProt Comments
Mediates resistance to sphinganine-analog mycotoxins (SAMs) by restoring the sphingolipid biosynthesis. Could salvage the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi apparatus in ceramides-depleted cells after SAM exposure .