NCBI Accession #
NP_186751.1
NCBI GenBank Nucleotide #
NM_110967.3
NCBI Official Full Name
ISCU-like 2
NCBI Official Symbol
ISU2
NCBI Official Synonym Symbols
ATISU2; ISCU-like 2; ISCU-LIKE 2; T4P13.30; T4P13_30
NCBI Protein Information
ISCU-like 2
NCBI Summary
Encodes a mitochondrial protein similar to E.coli IscU. In bacteria, IscU is a scaffold protein accepting sulfur and iron to build a transient Fe-S cluster,which is subsequently transferred to a target apoprotein.
UniProt Synonym Gene Names
AtISU2; Protein ISCU-LIKE 2
UniProt Protein Name
Iron-sulfur cluster assembly protein 2
UniProt Synonym Protein Names
NifU-like N-terminal domain-containing protein ISU2; NifU-like protein ISU2
UniProt Primary Accession #
Q9MAB6
UniProt Secondary Accession #
Q2WEB4
UniProt Related Accession #
Q9MAB6
UniProt Comments
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:17417719). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU (ISU1, ISU2 or ISU3). In a second step, the cluster is released from ISCU, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH .