Inositol-tetrakisphosphate 1-kinase 1 (ITPK1), Recombinant Protein
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Inositol-tetrakisphosphate 1-kinase 1 (ITPK1), Recombinant Protein

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Cat: RP10628
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Zea mays (Maize)
Datasheet:

Product Info

Full Product Name
Recombinant Zea mays Inositol-tetrakisphosphate 1-kinase 1 (ITPK1)
Product Gene Name
ITPK1 recombinant protein
Product Synonym Gene Name
ITPK1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MASDAAAEPS SGVTHPPRYV IGYALAPKKQ QSFIQPSLVA QAASRGMDLV PVDASQPLAE QGPFHLLIHK LYGDDWRAQL VAFAARHPAV PIVDPPHAID RLHNRISMLQ VVSELDHAAD QDSTFGIPSQ VVVYDAAALA DFGLLAALRF PLIAKPLVAD GTAKSHKMSL VYHREGLGKL RPPLVLQEFV NHGGVIFKVY VVGGHVTCVK RRSLPDVSPE DDASAQGSVS FSQVSNLPTE RTAEEYYGEK SLEDAVVPPA AFINQIAGGL RRALGLQLFN FDMIRDVRAG DRYLVIDINY FPGYAKMPGY ETVLTDFFWE MVHKDGVGNQ QEEKGANHVV VK
Sequence Positions
1-342, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
37,313 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Inositol-tetrakisphosphate 1-kinase

NCBI/Uniprot Data

NCBI Accession #
NP_001105901.1
NCBI GI #
162459062
NCBI GenBank Nucleotide #
NM_001112431.2
NCBI GeneID
732818
NCBI Official Full Name
inositol-tetrakisphosphate 1-kinase 1
NCBI Official Symbol
lpa2
NCBI Official Synonym Symbols
ITPK1; GRMZM2G456626
NCBI Protein Information
inositol-tetrakisphosphate 1-kinase 1
UniProt Gene Name
ITPK1
UniProt Synonym Gene Names
LPA2; Inositol-triphosphate 5/6-kinase 1; Ins(1,3,4)P(3) 5/6-kinase 1
UniProt Protein Name
Inositol-tetrakisphosphate 1-kinase 1
UniProt Synonym Protein Names
Inositol 1,3,4-trisphosphate 5/6-kinase 1 (EC:2.7.1.159); Inositol-triphosphate 5/6-kinase 1; Ins(1,3,4)P(3) 5/6-kinase 1; Low phytic acid protein 2; ZmIpk
UniProt Primary Accession #
Q84Y01
UniProt Related Accession #
Q84Y01
UniProt Comments
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 and participates in phytic acid biosynthesis in developing seeds. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl- channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also able to phosphorylate Ins(3,5,6)P3 but not Ins(1,4,5)P3, Ins(2,4,5)P3, Ins(1,3,4,6)P4 nor Ins(1,3,5,6)P4. Has higher specific activity on Ins(3,4,5,6)P4 than Ins(1,3,4)P3 and Ins(3,5,6)P3. Can also could use Ins(1,2,5,6)P4 as a substrate.

For research use only, not for clinical use.