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Histone-lysine N-methyltransferase SUVR2 (SUVR2), Recombinant Protein
Cat: RP05688
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase SUVR2 (SUVR2) , partial
Product Gene Name
SUVR2 recombinant protein
Product Synonym Gene Name
SUVR2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
79,363 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Probable inactive histone-lysine N-methyltransferase
NCBI/Uniprot Data
NCBI Accession #
NP_001078702.1
NCBI GI #
145334713
NCBI GenBank Nucleotide #
NM_001085233.2
NCBI GeneID
834422
NCBI Official Full Name
SET-domain containing protein lysine methyltransferase family protein
NCBI Official Symbol
SUVR2
NCBI Official Synonym Symbols
MRH10.10; MRH10_10; SDG18; SET DOMAIN PROTEIN 18
NCBI Protein Information
SET-domain containing protein lysine methyltransferase family protein
NCBI Summary
Encodes SUVR2, one of the four closely related Arabidopsis SUVR proteins that belong to the SU(VAR)3-9 subgroup of SET-domain proteins. Proteins containing the evolutionarily conserved SET domain are involved in regulation of eukaryotic gene expression and chromatin structure through their histone lysine methyltransferase (HMTase) activity. SUVR1, SUVR2 and SUVR4 proteins contain a novel domain at their N-terminus, and a SUVR specific region preceding the SET domain. Localized to the nucleolus, maybe involved in regulation of rRNA expression.
UniProt Gene Name
SUVR2
UniProt Synonym Gene Names
SDG18; SET18; Su(var)3-9-related protein 2
UniProt Protein Name
Probable inactive histone-lysine N-methyltransferase SUVR2
UniProt Synonym Protein Names
Protein SET DOMAIN GROUP 18; Suppressor of variegation 3-9-related protein 2; Su(var)3-9-related protein 2
UniProt Primary Accession #
Q9FNC7
UniProt Secondary Accession #
Q0WKU5; Q941L4
UniProt Related Accession #
Q9FNC7
UniProt Comments
Probable inactive histone-lysine methyltransferase that acts as regulator of transctiptional gene silencing independently of histone H3K9 methylation. Contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. Forms a complex with SUVR1 and associates with the SNF2-related chromatin-remodeling proteins CHR19, CHR27, and CHR28, thereby mediating nucleosome positioning and transcriptional silencing. Does not possess histone-lysine methyltransferase activity in vitro, and the conserved catalytic sites of SUVR2 are dispensable for its function in transcriptional gene silencing.
For research use only, not for clinical use.