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Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 (SUVH4), Recombinant Protein
Cat: RP03895
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 (SUVH4) , partial
Product Gene Name
SUVH4 recombinant protein
Product Synonym Gene Name
SUVH4
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
70,056 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Histone-lysine N-methyltransferase
NCBI/Uniprot Data
NCBI Accession #
NP_196900.1
NCBI GI #
15240758
NCBI GenBank Nucleotide #
NM_121399.3
NCBI GeneID
831244
NCBI Official Full Name
histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein
NCBI Official Symbol
SUVH4
NCBI Official Synonym Symbols
KRYPTONITE; KYP; MAC12.7; MAC12_7; SDG33; SET DOMAIN PROTEIN 33; SU(VAR)3-9 homolog 4
NCBI Protein Information
histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein
NCBI Summary
Encodes a histone 3 lysine 9 specific methyltransferase involved in the maintenance of DNA methylation. SUVH4/KYP is a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain. In kyp mutants, there is a loss of CpNpG methylation. The protein was shown to bind to methylated cytosines of CG, CNG and CNN motifs via its SRA domain but has a preference for the latter two. There is also evidence that KYP/SUVH4 might be involved in the telomerase-independent process known as Alternative Lengthening of Telomeres.
UniProt Gene Name
SUVH4
UniProt Synonym Gene Names
KYP; SDG33; SET33; H3-K9-HMTase 4; Su(var)3-9 homolog protein 4
UniProt Protein Name
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4
UniProt Synonym Protein Names
Histone H3-K9 methyltransferase 4; H3-K9-HMTase 4; Protein KRYPTONITE; Protein SET DOMAIN GROUP 33; Suppressor of variegation 3-9 homolog protein 4; Su(var)3-9 homolog protein 4
UniProt Primary Accession #
Q8GZB6
UniProt Secondary Accession #
Q9C5P3; Q9FFX9
UniProt Related Accession #
Q8GZB6
UniProt Comments
Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an HP1-like adapter. By its function, KYP is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. Involved in the silencing of transposable elements.
For research use only, not for clinical use.