Histone-lysine N-methyltransferase, H3 lysine-9, H3 lysine-27, H4 lysine-20 and cytosine specific SUVH2 (SUVH2), Recombinant Protein
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Histone-lysine N-methyltransferase, H3 lysine-9, H3 lysine-27, H4 lysine-20 and cytosine specific SUVH2 (SUVH2), Recombinant Protein

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Cat: RP03952
Size: 0.5 mg (E-Coli)/ 0.05 mg (Baculovirus)/ 0.5 mg (Yeast)/ 0.05 mg (Mammalian-Cell)/ 1 mg (E-Coli)/ 0.1 mg (Baculovirus)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 0.5 mg (Baculovirus)/ 1 mg (Baculovirus)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase, H3 lysine-9, H3 lysine-27, H4 lysine-20 and cytosine specific SUVH2 (SUVH2) , partial
Product Gene Name
SUVH2 recombinant protein
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
TGCECKLSCT DDCLCARKNG GEFAYDDNGH LLKGKHVVFE CGEFCTCGPS CKSRVTQKGL RNRLEVFRSK ETGWGVRTLD LIEAGAFICE YAGVVVTRLQ AEILSMNGDV MVYPGRFTDQ WRNWGDLSQV YPDFVRPNYP SLPPLDFSMD VSRMRNVACY ISHSKEPNVM VQFVLHDHNH LMFPRVMLFA LENISPLAEL SLDYG
Sequence Positions
434-638. Partial, including the Pre-SET domain and SET domain
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
72,848 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Histone-lysine N-methyltransferase family

NCBI/Uniprot Data

NCBI Accession #
NP_001318341.1
NCBI GI #
1063702149
NCBI GenBank Nucleotide #
NM_001336444.1
NCBI GeneID
817892
NCBI Official Full Name
SU(VAR)3-9 homolog 2
NCBI Official Symbol
SUVH2
NCBI Official Synonym Symbols
ATSUVH2; F4P9.6; F4P9_6; SDG3; SET DOMAIN-CONTAINING PROTEIN 3; SU(VAR)3-9 homolog 2
NCBI Protein Information
SU(VAR)3-9 homolog 2
NCBI Summary
Encodes a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression and act as histone methyltransferases. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain. Gene is expressed in rosettes, stems, floral buds, and flowers by RT-PCR.
UniProt Gene Name
SUVH2
UniProt Synonym Gene Names
SDG3; SET3; H3-K9-HMTase 2; Su(var)3-9 homolog protein 2
UniProt Protein Name
Histone-lysine N-methyltransferase family member SUVH2
UniProt Synonym Protein Names
Cytosine-HMTase 2; H3-K27-HMTase 2; H4-K20-HMTase 2; Histone H3-K9 methyltransferase 2; H3-K9-HMTase 2; Protein SET DOMAIN GROUP 3; Suppressor of variegation 3-9 homolog protein 2; Su(var)3-9 homolog protein 2
UniProt Primary Accession #
O22781
UniProt Related Accession #
O22781
UniProt Comments
Histone methyltransferase family member that plays a central role in gene silencing (PubMed:15775980, PubMed:16384625, PubMed:19043555, PubMed:24463519, PubMed:27171427). Together with MORC6 and SUVH9, regulates the silencing of some transposable elements (TEs) (PubMed:27171427). According to PubMed:15775980, it is required for normal methylation of 'Lys-9' and 'Lys-27' of histone H3, 'Lys-20' of H4, and cytosine, but PubMed:19043555 see no significant effect on histone methylation when the gene is mutated. According to PubMed:19043555, the protein does not bind S-adenosyl-L-methionine and lacks methyltransferase activity. Instead, it may function downstream of DRM2 in RNA-directed DNA methylation, binding to methylated DNA and recruiting DNA-directed RNA polymerase V to chromatin (PubMed:24463519, PubMed:27171427).

For research use only, not for clinical use.