Histone deacetylase 6 (HDA6), Recombinant Protein
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Histone deacetylase 6 (HDA6), Recombinant Protein

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Cat: RP02659
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Yeast)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Histone deacetylase 6 (HDA6)
Product Gene Name
HDA6 recombinant protein
Product Synonym Gene Name
HDA6
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MEADESGISL PSGPDGRKRR VSYFYEPTIG DYYYGQGHPM KPHRIRMAHS LIIHYHLHRR LEISRPSLAD ASDIGRFHSP EYVDFLASVS PESMGDPSAA RNLRRFNVGE DCPVFDGLFD FCRASAGGSI GAAVKLNRQD ADIAINWGGG LHHAKKSEAS GFCYVNDIVL GILELLKMFK RVLYIDIDVH HGDGVEEAFY TTDRVMTVSF HKFGDFFPGT GHIRDVGAEK GKYYALNVPL NDGMDDESFR SLFRPLIQKV MEVYQPEAVV LQCGADSLSG DRLGCFNLSV KGHADCLRFL RSYNVPLMVL GGGGYTIRNV ARCWCYETAV AVGVEPDNKL PYNEYFEYFG PDYTLHVDPS PMENLNTPKD MERIRNTLLE QLSGLIHAPS VQFQHTPPVN RVLDEPEDDM ETRPKPRIWS GTATYESDSD DDDKPLHGYS CRGGATTDRD STGEDEMDDD NPEPDVNPPS S
Sequence Positions
1-471, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
52,652 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Histone deacetylase

NCBI/Uniprot Data

NCBI Accession #
NP_201116.1
NCBI GI #
15242626
NCBI GenBank Nucleotide #
NM_125705.4
NCBI GeneID
836431
NCBI Official Full Name
histone deacetylase 6
NCBI Official Symbol
HDA6
NCBI Official Synonym Symbols
ATHDA6; AXE1; histone deacetylase 6; HISTONE DEACETYLASE 6; MDC12.7; MDC12_7; RNA-MEDIATED TRANSCRIPTIONAL SILENCING 1; RPD3B; RTS1; SIL1
NCBI Protein Information
histone deacetylase 6
NCBI Summary
RPD3-like histone deacetylase. HDA6 mutations specifically increase the expression of auxin-responsive transgenes, suggesting a role in transgene silencing.
UniProt Gene Name
HDA6
UniProt Synonym Gene Names
RPD3B
UniProt Protein Name
Histone deacetylase 6
UniProt Primary Accession #
Q9FML2
UniProt Secondary Accession #
Q9FVE5
UniProt Related Accession #
Q9FML2
UniProt Comments
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Might remove acetyl residues only from specific targets, such as rDNA repeats or complex transgenes. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for rRNA gene silencing in nucleolar dominance. Plays a role in transgene silencing, but this effect seems to bee independent of the histone deacetylase activity (PubMed:11340181, PubMed:12486004, PubMed:15037732, PubMed:16648464). Part of the AS1 repressor complex to regulate the KNOX expression in leaf development (PubMed:23271976). Binds to KNAT1, KNAT2, and KNATM chromatin (PubMed:23271976).

For research use only, not for clinical use.