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Histone acetyltransferase GCN5 (HAG1), Recombinant Protein
Cat: RP02609
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Histone acetyltransferase GCN5 (HAG1) , partial
Product Gene Name
HAG1 recombinant protein
Product Synonym Gene Name
HAG1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
63,124 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Hemagglutinin
NCBI/Uniprot Data
NCBI Accession #
NP_567002.1
NCBI GI #
18410098
NCBI GenBank Nucleotide #
NM_115318.3
NCBI GeneID
824626
NCBI Official Full Name
histone acetyltransferase of the GNAT family 1
NCBI Official Symbol
HAG1
NCBI Official Synonym Symbols
BGT; BIG TOP; GCN5; general control non-repressible 5; HAC3; HAG01; HAT1; HISTONE ACETYLTRANSFERASE 1; histone acetyltransferase of the GNAT family 1
NCBI Protein Information
histone acetyltransferase of the GNAT family 1
NCBI Summary
Encodes a histone acetyltransferase that is plays a role in the determination of the embryonic root-shoot axis. It is also required to regulate the floral meristem activity by modulating the extent of expression of WUS and AG. In other eukaryotes, this protein is recruited to specific promoters by DNA binding transcription factors and is thought to promote transcription by acetylating the N-terminal tail of histone H3. The enzyme has indeed been shown to catalyse primarily the acetylation of H3 histone with only traces of H4 and H2A/B being acetylated. Non-acetylated H3 peptide or an H3 peptide that had been previously acetylated on K9 both serve as excellent substrates for HAG1-catalyzed acetylation. However, prior acetylation of H3 lysine 14 blocks radioactive acetylation of the peptide by HAG1. HAG1 is specific for histone H3 lysine 14.
UniProt Gene Name
HAG1
UniProt Synonym Gene Names
BGT; GCN5; HAT1; AtGCN5
UniProt Protein Name
Histone acetyltransferase GCN5
UniProt Synonym Protein Names
BIG TOP protein
UniProt Primary Accession #
Q9AR19
UniProt Secondary Accession #
O22654; Q7G1G9; Q9M1G7
UniProt Related Accession #
Q9AR19
UniProt Comments
Acetylates histone H3 and ADA2 proteins in vitro. Acetylates 'Lys-14' of histone H3. Acetylation of histones gives a specific tag for epigenetic transcription activation. Operates in concert with certain DNA-binding transcriptional activators. Acts via the formation of large multiprotein complexes that modify the chromatin .
For research use only, not for clinical use.