NCBI Accession #
NP_001190417.1
NCBI GenBank Nucleotide #
NM_001203488.1
NCBI Official Full Name
GDP-D-mannose 3',5'-epimerase
NCBI Official Synonym Symbols
''GDP-D-mannose 3'; 5'-epimerase; 5'-epimerase''; F7P1.20; F7P1_20; GDP-D-mannose 3'
NCBI Protein Information
GDP-D-mannose 3',5'-epimerase
NCBI Summary
Encodes a protein with GDP-D-mannose 3',5'-epimerase activity. The enzyme is involved in ascorbate biosynthesis. It catalyzes the conversion of GDP-D-mannose to GDP-L-galactose.
UniProt Gene Name
At5g28840
UniProt Synonym Gene Names
GDP-Man 3,5-epimerase
UniProt Protein Name
GDP-mannose 3,5-epimerase
UniProt Primary Accession #
Q93VR3
UniProt Related Accession #
Q93VR3
UniProt Comments
Catalyzes a reversible epimerization of GDP-D-mannose that precedes the committed step in the biosynthesis of vitamin C (L-ascorbate), resulting in the hydrolysis of the highly energetic glycosyl-pyrophosphoryl linkage. Able to catalyze 2 distinct epimerization reactions and can release both GDP-L-galactose and GDP-L-gulose from GDP-mannose.