NCBI Accession #
NP_177468.2
NCBI GenBank Nucleotide #
NM_105984.4
NCBI Official Full Name
GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase 1
NCBI Official Symbol
GER1
NCBI Official Synonym Symbols
''GDP-4-keto-6-deoxymannose-3; 5-EPIMERASE-4-REDUCTASE; 5-epimerase-4-reductase 1; 5-epimerase-4-reductase 1''; ACTIVATING TRANSCRIPTION FACTOR 5; ATFX; GDP-4-KETO-6-DEOXY-D-MANNOSE-3; GDP-4-keto-6-deoxymannose-3; T18K17.8; T18K17_8
NCBI Protein Information
GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase 1
NCBI Summary
encodes a bifunctional 3, 5-epimerase-4-reductase in L-fucose synthesis and converts GDP-D-mannose to GDP-L-fucose in vitro along with MUR1 (GDP-D-mannose 4,6-dehydratase). It is expressed in all tissues examined, but most abundantly in roots and flowers.
UniProt Synonym Gene Names
FX; AtFX; AtGER1
UniProt Protein Name
GDP-L-fucose synthase 1
UniProt Synonym Protein Names
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase 1; AtFX; AtGER1
UniProt Primary Accession #
O49213
UniProt Secondary Accession #
Q0WQ67
UniProt Related Accession #
O49213
UniProt Comments
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Not involved in the synthesis of GDP-L-galactose from GDP-D-manose.