NCBI Accession #
NP_199908.1
NCBI GenBank Nucleotide #
NM_124474.4
NCBI Official Full Name
FUMARASE 2
NCBI Official Symbol
FUM2
NCBI Official Synonym Symbols
FUMARASE 2; K3K7.11; K3K7_11
NCBI Protein Information
FUMARASE 2
NCBI Summary
Encodes a fumarase enzyme initially shown to be in the mitochondria through proteomic studies but later shown to be present in the cytosol using an RFP fluorescent protein tag. It appears to be important for the accumulation of fumarate from malate in leaves in the light, and helps to promote nitrogen assimilation under high nitrogen conditions. It does not appear to be necessary for lipid metabolism and seedling growth.
UniProt Synonym Gene Names
Fumarase 2
UniProt Protein Name
Fumarate hydratase 2, chloroplastic
UniProt Primary Accession #
Q9FI53
UniProt Secondary Accession #
Q8VY72
UniProt Related Accession #
Q9FI53
UniProt Comments
MiscellaneousThere are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors .