NCBI Accession #
NP_567590.3
NCBI GenBank Nucleotide #
NM_118089.4
NCBI Official Full Name
iron-regulated transporter 1
NCBI Official Symbol
IRT1
NCBI Official Synonym Symbols
ARABIDOPSIS IRON-REGULATED TRANSPORTER 1; ATIRT1; iron-regulated transporter 1; T16H5.50; T16H5_50
NCBI Protein Information
iron-regulated transporter 1
NCBI Summary
The gene encodes Fe2+ transporter protein. It is a member of the Zrt/Irt-like protein (ZIP) family of transporters. AtIRT1 has broad specificity for divalent heavy metals, mediating the transport of zinc, manganese, cobalt and cadmium under Fe-deficient conditions. IRT1 is monoubiquitinated to promote endocytic trafficking.
UniProt Protein Name
Fe(2+) transport protein 1
UniProt Synonym Protein Names
Fe(II) transport protein 1; Iron-regulated transporter 1
UniProt Primary Accession #
Q38856
UniProt Secondary Accession #
Q8LBP0
UniProt Related Accession #
Q38856
UniProt Comments
High-affinity iron transporter that plays a key role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer. Acts as the principal regulator of iron homeostasis in planta. Also mediates the heavy metals uptake under iron-deficiency by its ability to transport cobalt, cadmium, manganese and/or zinc ions.