NCBI Accession #
NP_001105557.1
NCBI GenBank Nucleotide #
NM_001112087.2
NCBI Official Full Name
FACT complex subunit SPT16
NCBI Official Symbol
gtc102
NCBI Official Synonym Symbols
SPT16; GRMZM5G806358
NCBI Protein Information
FACT complex subunit SPT16
UniProt Synonym Gene Names
GTC102
UniProt Protein Name
FACT complex subunit SPT16
UniProt Synonym Protein Names
Facilitates chromatin transcription complex subunit SPT16; Global transcription factor group C protein 102
UniProt Primary Accession #
Q8H6B1
UniProt Related Accession #
Q8H6B1
UniProt Comments
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. SSRP1 binds specifically to double-stranded DNA .