NCBI Accession #
NP_192809.1
NCBI GenBank Nucleotide #
NM_117139.2
NCBI Official Full Name
FACT complex subunit SPT16
NCBI Official Symbol
SPT16
NCBI Official Synonym Symbols
global transcription factor C; SPT16; T12H20.3; T12H20_3
NCBI Protein Information
FACT complex subunit SPT16
NCBI Summary
encodes a component of the FAcilitates Chromatin Transcription (FACT) complex, SPT16.Along with SSRP1 binds to the promoter of FLC.
UniProt Protein Name
FACT complex subunit SPT16
UniProt Synonym Protein Names
Facilitates chromatin transcription complex subunit SPT16
UniProt Entry Name
SPT16_ARATH
UniProt Primary Accession #
O82491
UniProt Secondary Accession #
C0SVH5
UniProt Related Accession #
O82491
UniProt Comments
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (Probable).