NCBI Accession #
NP_567005.2
NCBI GenBank Nucleotide #
NM_115322.4
NCBI Official Full Name
RNI-like superfamily protein
NCBI Official Symbol
FBL17
NCBI Protein Information
RNI-like superfamily protein
UniProt Protein Name
F-box/LRR-repeat protein 17
UniProt Synonym Protein Names
F-box-like protein 17
UniProt Primary Accession #
Q8W104
UniProt Secondary Accession #
Q9M1T4
UniProt Related Accession #
Q8W104
UniProt Comments
Essential protein for male fertility. Component of the SCF(ASK-cullin-F-box) E3 ubiquitin ligase complex SCF(FBL17), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Enables the switch in cell cycle control leading to male germ cell lineage formation from microspores after meiosis. Targets CDKA-1 inhibitors the degradation specifically in male germ cells (e.g. KRP6 and KRP7) and thus enables CDKA-1 activation and germ cell S-phase progression. Promotes twin sperm cell production and double fertilization.