NCBI Accession #
NP_182151.1
NCBI GenBank Nucleotide #
NM_130191.6
NCBI Official Full Name
TGF-beta receptor interacting protein 1
NCBI Official Symbol
TRIP-1
NCBI Official Synonym Symbols
T3F17.7; TGF-beta receptor interacting protein 1; TIF3I1; TRIP1
NCBI Protein Information
TGF-beta receptor interacting protein 1
NCBI Summary
Encodes a homolog of mammalian TGF-beta receptor interacting protein. Co-immunoprecipitates with BRI1 and can be phosphorylated in vitro by BRI1 at specific sites (Thr-14, Thr-89, and either Thr-197 or Ser-198). May therefore be a cytoplasmic BRI1 substrate and involved in brassinosteroid regulated plant growth and development.The encoded protein has two DWD motifs. It can bind to DDB1a in Y2H assays, and DDB1b in co-IP assays, and may be involved in the formation of a CUL4-based E3 ubiquitin ligase
UniProt Synonym Gene Names
eIF3i; TRIP-1
UniProt Protein Name
Eukaryotic translation initiation factor 3 subunit I
UniProt Synonym Protein Names
Eukaryotic translation initiation factor 3 subunit 2
UniProt Primary Accession #
Q38884
UniProt Secondary Accession #
O82342; Q94K09; Q9C5Z0
UniProt Related Accession #
Q38884
UniProt Comments
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.