NCBI Accession #
NP_001078610.1
NCBI GenBank Nucleotide #
NM_001085141.1
NCBI Official Full Name
eukaryotic translation initiation factor 2 beta subunit
NCBI Official Symbol
EIF2 BETA
NCBI Official Synonym Symbols
EMB1401; embryo defective 1401; eukaryotic translation initiation factor 2 beta subunit; F22D1.90; F22D1_90
NCBI Protein Information
eukaryotic translation initiation factor 2 beta subunit
NCBI Summary
protein synthesis initiation factor eIF2 beta
UniProt Synonym Gene Names
EMB1401Curated; eIF2-betaCurated
UniProt Protein Name
Eukaryotic translation initiation factor 2 subunit beta
UniProt Synonym Protein Names
Protein EMBRYO DEFECTIVE 1401Curated
UniProt Primary Accession #
Q41969
UniProt Secondary Accession #
Q8L7Q3; Q9C5N7; F4K6W6
UniProt Related Accession #
Q41969
UniProt Comments
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B .