NCBI Accession #
                                                
                                                
                                                    NP_001078610.1                                                
                                             
                                                                                    
                                                                                    
                                                
                                                    NCBI GenBank Nucleotide #
                                                
                                                
                                                    NM_001085141.1                                                
                                             
                                                                                    
                                                                                    
                                                
                                                    NCBI Official Full Name
                                                
                                                
                                                    eukaryotic translation initiation factor 2 beta subunit                                                
                                             
                                                                                    
                                                
                                                    NCBI Official Symbol
                                                
                                                
                                                    EIF2 BETA                                                
                                             
                                                                                    
                                                
                                                    NCBI Official Synonym Symbols
                                                
                                                
                                                    EMB1401; embryo defective 1401; eukaryotic translation initiation factor 2 beta subunit; F22D1.90; F22D1_90                                                
                                             
                                                                                    
                                                
                                                    NCBI Protein Information
                                                
                                                
                                                    eukaryotic translation initiation factor 2 beta subunit                                                
                                             
                                                                                    
                                                
                                                    NCBI Summary
                                                
                                                
                                                    protein synthesis initiation factor eIF2 beta                                                
                                             
                                                                                    
                                                                                    
                                                
                                                    UniProt Synonym Gene Names
                                                
                                                
                                                    EMB1401Curated; eIF2-betaCurated                                                
                                             
                                                                                    
                                                
                                                    UniProt Protein Name
                                                
                                                
                                                    Eukaryotic translation initiation factor 2 subunit beta                                                
                                             
                                                                                    
                                                
                                                    UniProt Synonym Protein Names
                                                
                                                
                                                    Protein EMBRYO DEFECTIVE 1401Curated                                                
                                             
                                                                                    
                                                
                                                    UniProt Primary Accession #
                                                
                                                
                                                    Q41969                                                
                                             
                                                                                    
                                                
                                                    UniProt Secondary Accession #
                                                
                                                
                                                    Q8L7Q3; Q9C5N7; F4K6W6                                                
                                             
                                                                                    
                                                
                                                    UniProt Related Accession #
                                                
                                                
                                                    Q41969                                                
                                             
                                                                                    
                                                
                                                    UniProt Comments
                                                
                                                
                                                    eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B .