NCBI Accession #
NP_195948.1
NCBI GenBank Nucleotide #
NM_120406.5
NCBI Official Full Name
NRAMP metal ion transporter family protein
NCBI Official Symbol
EIN2
NCBI Official Synonym Symbols
ATEIN2; CKR1; CYTOKININ RESISTANT 1; ENHANCED RESPONSE TO ABA3; ERA3; ETHYLENE INSENSITIVE 2; F12E4.10; F12E4_10; ORE2; ORE3; ORESARA 2; ORESARA 3; PIR2
NCBI Protein Information
NRAMP metal ion transporter family protein
NCBI Summary
Involved in ethylene signal transduction. Acts downstream of CTR1. Positively regulates ORE1 and negatively regulates mir164A,B,C to regulate leaf senescence. A maternally expressed imprinted gene. Mutations in ein2 block ethylene stimulation of flavonol synthesis.
UniProt Synonym Gene Names
EIN-2
UniProt Protein Name
Ethylene-insensitive protein 2
UniProt Synonym Protein Names
EIN2C
UniProt Primary Accession #
Q9S814
UniProt Related Accession #
Q9S814
UniProt Comments
Central factor in signaling pathways regulated by ethylene (ET), and involved in various processes including development, plant defense, senescence, nucleotide sugar flux, and tropisms. Necessary for ethylene-mediated gene regulation, and for the induction of some genes by ozone. Acts downstream of ET receptors, and upstream of ethylene regulated transcription factors. Required for cytokinin-mediated processes. Seems to be implicated in cross-talk between ET, jasmonate and other pathways. Probably not involved in iron uptake (PubMed:10381874, PubMed:12953109, PubMed:14973160, PubMed:15010611, PubMed:15272873, PubMed:7770519, PubMed:9351240). Has a short half-life and undergoes rapid proteasome-mediated turnover in the absence of ethylene (PubMed:19196655). Required for ethylene-induced EIN3 stabilization via proteasomal degradation of EBF1/EBF2 proteins (PubMed:20647342). Regulates the leaf senescence induced by methyl jasmonate, ethylene and abscisic acid (Ref. 17, PubMed:15010611).