NCBI Accession #
NP_189124.1
NCBI GenBank Nucleotide #
NM_113392.3
NCBI Official Full Name
proteolysis 1
NCBI Official Symbol
PRT1
NCBI Official Synonym Symbols
proteolysis 1
NCBI Protein Information
proteolysis 1
NCBI Summary
Contains two ring finger domains and one ZZ domain. Week similarity to yeast Rad18p. Putative component of the N-end rule pathway (ubiquitin-dependent proteolysis).
UniProt Protein Name
E3 ubiquitin-protein ligase PRT1
UniProt Synonym Protein Names
Proteolysis 1 protein; RING-type E3 ubiquitin transferase PRT1Curated
UniProt Primary Accession #
Q8LBL5
UniProt Secondary Accession #
O82767
UniProt Related Accession #
Q8LBL5
UniProt Comments
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. Functions in the N-end rule pathway of protein degradation, where it specifically recognizes and ubiquitinates proteins with a N-terminal bulky aromatic amino acid (Phe). Does not act on aliphatic hydrophobic and basic N-terminal residues (Arg or Leu) containing proteins.